The first preserved historical document that tells us about the primitive Church of Santa María la Blanca dates from the 15th century, specifically from 1461 in the will of D. Lázaro Sánchez Escribano, steward of the nearby Charity Hospital. It is even possible that a mosque was previously located on the same site. The current building dates from 1627, the year in which it was rebuilt due to the poor state of the original church and was built with a single nave, flat chancel, choir at the base, barrel vault with lunettes and two very classical Baroque doorways. In 1752 it underwent a new reform without major structural changes. In the same century, its title changed to the current one, the Immaculate Conception.

Inside, there was a three-part Baroque altarpiece attributed to the workshop of Alonso Cano, which was unfortunately lost in the fire that devastated the church in 1991, as were the images of worship that were in the building. Among the current images are those of San José and Ntra. Sra. del Rosario, which were saved from the fire because they were in another temple, and the processional images of Ntro. Padre Jesús Nazareno, a cedar wood carving made in 1991 by Miguel Ángel González Jurado, and the image of Cristo de la Vera Cruz, carved by Miguel Arjona in 1993.

The interior of the church can be visited outside worship hours and in group visits by prior arrangement with the Guadalquivir Valley Visitor Centre.